return to OT Resource

Gabapentin in orthostatic tremor: results of a double-blind crossover


with placebo in four patients. Onofrj M, Thomas A, Paci C, D'Andreamatteo G Department of Oncology
and Neuroscience, University G. D'Annunzio Chieti, Italy. We treated four patients affected by orthostatic
tremor (OT) with gabapentin in increasing doses (300 to 2,400 mg/d). OT was evaluated with patients'
self-monitoring scales, tremor rating scales, electromyography (EMG) showing the 14- to 18-Hz
frequencies, and EMG frequency analysis. All patients had transitory responses to clonazepam.
Gabapentin induced disappearance of OT in three patients and consistent reduction in one. Crossover to
placebo induced reappearance of tremor. PMID: 9748048, UI: 98418844

return to OT Resource


Neurology 1998 Sep;51(3):880-2